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CB2R PAM
CAS No. 2244579-87-9
CB2R PAM( —— )
Catalog No. M34909 CAS No. 2244579-87-9
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 78 | Get Quote |
|
| 5MG | 116 | Get Quote |
|
| 10MG | 170 | Get Quote |
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| 25MG | 271 | Get Quote |
|
| 50MG | 412 | Get Quote |
|
| 100MG | 593 | Get Quote |
|
| 500MG | 1242 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCB2R PAM
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NoteResearch use only, not for human use.
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Brief DescriptionCB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists.
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DescriptionCB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.
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In VitroCB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs.
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In VivoCB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity.Animal Model:Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model) Dosage:1, 5, 10, 20 mg/kg Administration:P.o.Result:Significantly increased licking latency in the animals starting from 5 mg/kg.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2244579-87-9
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Formula Weight435.33
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Molecular FormulaC21H24BrFN2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (114.86 mM; Ultrasonic )
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SMILESN(C(=O)C1CCCCCC1)C=2C(=O)N(CC3=CC=C(F)C=C3)C=C(Br)C2C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62(1):276-287.?
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